Principal Investigator

劉勃佑 Po-Yu Liu, PhD
Assistant Professor

Education & Academic Experiences

Assistant Professor (2023-)
 School of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan
PostDoc (2022-2023)
 Biodiversity Research Center, Academia Sinica, Taipei, Taiwan
Visiting Scholar (2021-2022)
 Royal Veterinary College (RVC), University of London, UK
 The London School of Hygiene and Tropical Medicine (LSHTM), UK
研發替代役/PostDoc (2019-2022)
 Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

PhD (2014-2019) Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica
MSc (2012-2014) Department of Life Science (former Institute of Zoology), National Taiwan University
BSc (2008-2012) Biomedical Science and Environmental Biology & Public Health (Dual degree), Kaohsiung Medical University

Biography

Po-Yu Liu, PhD, is an Assistant Professor at the School of Medicine, College of Medicine, National Sun Yat-sen University (NSYSU), Taiwan. His research integrates clinical microbiome studies, ecological microbiology, and computational biology, emphasizing multi-omics approaches to understand how microbial communities influence health, disease, and environmental adaptation. He collaborates with multiple medical centers on translational microbiome projects related to gynecology, nephrology, hepatology, and head-and-neck oncology, with particular focus on gut microbiota in chronic kidney disease and metabolic dysfunction–associated steatotic liver disease (MASLD).

Po-Yu received dual bachelor's degrees in Biology and Public Health from Kaohsiung Medical University, an MSc in Zoology/Life Science, and a PhD in Genome and Systems Biology from National Taiwan University (PhD: NTU and Academia Sinica). His doctoral research investigated host–microbiota interactions using integrated multi-omics analyses, including next-generation sequencing and metabolomics, to elucidate microbial ecology and metabolic crosstalk in mammalian systems.

After completing his PhD in 2019, he joined the National Taiwan University College of Medicine as a bioinformatician, participating in a wide range of human disease-associated microbiota studies. He later conducted academic visits at the Royal Veterinary College and the London School of Hygiene and Tropical Medicine in the United Kingdom, where he led multi-omics integration projects linking microbiome, metabolome, and host data to identify potential biomarkers of anti-parasite vaccine therapeutic targets.

Currently, his laboratory at NSYSU is developing a novel invertebrate model to explore the colonization dynamics of gut microbiota through Nanopore sequencing and other omics technologies. Guided by the “One Health” framework, Po-Yu’s research aims to bridge human, animal, and environmental microbiomes through cross-disciplinary, multi-omics integration to advance precision medicine and ecological understanding.

Honours

  1. 5th International Wildlife Management Congress (2015 IWMC) Student Leaders Award
  2. 2015 IWMC budget rewarded by Ministry of Science and Technology (MOST 104-2922-I-002 -374), Taiwan (NT$26,900)
  3. EMBO|EMBL Symposium of New Approaches and Concepts in Microbiology Travel Grants (€1,000)
  4. 16th International Symposium on Microbial Ecology (2016 ISME) Travel Grants (€750)
  5. EMBO Practical Course on Metabolomics Bioinformatics for Life Sciences Travel Grants (€1,000)
  6. EMBO | EMBL Symposium: Multiomics to Mechanisms - Challenges in Data Integration Travel Grants (€600)

Grants

  國科會 National Science and Technology Council

  1. 112年度國家科學及技術委員會新進人員研究計畫：以大蠟蛾建立腸道微生物相最小功能群定植之模式動物、並以奈米孔定序分析定植微生物相之動態 (計畫主持人) (2023/10-2024/9)
  2. 112年度國家科學及技術委員會專題研究計畫：以壟鼠(Arvicanthis niloticus)多體學分析瞭解哺乳動物適應性演化的分子基礎、並建立第一個適於研究代謝以及睡眠疾病的純品系日行性鼠科模式動物 (共同主持人) (2023/8-2026/7)
  3. 113年度國家科學及技術委員會「微生物相在精準健康之研發及應用」專案計畫：腎臟病病人的腸道菌與尿毒素代謝體的臨床使用多重生物標記開發(1/4) (共同主持人)
  4. 113年度國家科學及技術委員會專題研究計畫：探索尿液微菌對腎功能下降和蛋白尿惡化的影響 (共同主持人) (2024/8-2027/7)
  5. 113年度國家科學及技術委員會專題研究計畫：以大蠟蛾建立腸道微生物相最小功能群定植之模式動物、並以奈米孔定序分析定植微生物相之動態-延續計畫 (計畫主持人) (2024/8-2027/7)
  6. 114年度國家科學及技術委員會「微生物相在精準健康之研發及應用」專案計畫：腎臟病病人的腸道菌與尿毒素代謝體的臨床使用多重生物標記開發(2/4) (共同主持人)
  7. 114年度國家科學及技術委員會產學技術聯盟合作計畫：精準營養產業技術發展聯盟(1/3) (共同主持人)
  8. 114年度國家科學及技術委員會專題研究計畫：臨床多體學平台的開發與應用：以慢性塑膠微粒暴露之腸肝和腸腦軸健康效應為例 (共同主持人)
  9. 114年度國家科學及技術委員會專題研究計畫：腸道菌體學與代謝體學整合分析:探討其對蛋白尿形成的影響與機制 (共同主持人)

  醫院合作計畫

  1. 112年高雄長庚醫院院內研究計畫：以表徵飲食型態和腸道微生物特徵之精準營養策略識別自發性早產的保護性及危險因子 (共同主持人) (2023/12-2025/11)
  2. 113年國立中山大學/高雄長庚醫院合作計畫：以腸道微生物相及血清脂質體組成探討瘦型代謝異常脂肪肝疾病風險之宿主微生物相互作用線索 (中山大學方主持人) (2024/1-2024/12)
  3. 113年度輔仁大學附設醫院院內研究計畫：探討頭頸鱗狀細胞癌病人口腔及腸道菌相與癌症治療反應的關聯 (共同主持人) (2024/8-2025/7)

Expertise

Metagenomics, Microbiota, Microbial Ecology, NGS/3rd-gen sequencing, Multi-Omics integration

Invited talks

  Academic speeches

  1. 2023 International Symposium on Evolutionary Genomics and Bioinformatics (ISEGB2023) by National Tsing-Hua University and Taiwan Society of Evolution and Computational Biology (TSECB), Hsinchu, Taiwan, June 29-30, 2023 Link
  2. 臺北醫學大學醫學資訊研究所邀請演講 112/10/5 15:30 ~ 17:00
  3. 2023年長庚體系醫學教育研究線上微型研究會議 by 長庚醫學教育研究中心 Online, November 24, 2023
  4. 2024 MiTalk8 by 慈濟大學, 花蓮, January 18-19, 2024 Link
  5. 國立臺灣大學生命科學系博碩士班專題討論暨椰林菁英計畫邀請演講 2024/3/22 (Fri.) 13:30 ~ 15:00 Link
  6. 2024第7屆台灣微菌聯盟學術年會暨第2屆亞太微菌聯盟學術研討會 Challenges and Unmet Needs of Microbiome Research in the Era of Precision Health by 台灣微菌聯盟 Taiwan Microbiota Consortium, Kaohsiung, Taiwan, April 27, 2024 Link
  7. 國立臺灣大學植物病理與微生物學系碩士班專題討論邀請演講 2024/5/2 (Thu.) 11:20 ~ 12:10
  8. Seminar on 'Multi-omics analysis' at Faculty of Medical Technology, Prince of Songkla University (PSU), Thailand. July 26th, 2024.
  9. Seminar on 'Multi-omics analysis of an anticoccidial vaccination trial' at Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Thailand. Augest 2nd, 2024.
  10. Deciphering Ecological and Functional Complementarity of Microbiomes via Integrative Multi-Omics Approaches 圖爾斯生技2025巡迴演講 微生物多體學新視界：探索基因、功能與代謝的奧秘 April 29, 2025 Link

    11. 2025biotools
  11. 15th Asian Symposium on Microbial Ecology (ASME2025) by Chungbuk National University and The Microbiology Societyof Korea (MSK), Cheongju, South Korea, May 28-30, 2025 Link
    asme2025

  Popular science speeches

  1. 從自然到日常： 不買益生菌也能養好菌？台灣科技媒體中心 SciComm Today 實體講座 September 19, 2024 Link

    2. SciComm Today